Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper

Bamboo shoots of Dendrocalamus asper is very important for human health because its high content dietary fiber, low sugar, negligible amount fat, rich in vitamins and minerals. In search new potential antimalarial agents, the chemical constituents bamboo were evaluated againts P. falciparum strain 3D7. One metabolite, (11E,13E,17E,19E)-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate (1) along with four known compounds; β-sitosterol (2), methyl-4-hydroxybenzoate (3), 1-methoxy-4-(methoxymethyl)benzene (4) 4-hydroxybenzaldehyde (5) isolated from crude extract using chromatographic methods: MPLC, UPLC/MS, analytical preparative HPLC. Among these, compounds 1, 3 4 showed promising activity IC50 between 0.8-2.2 μg/mL. The molecular docking most potent compound dihydrofolate reductase-thymidylate synthase (DHFR-TS) was done to understand exploring ligand-receptor interactions hypothesize compound's refinements